Our group focuses on the characterization of biological pathways and mechanisms using genomics, bioinformatics and machine learning approaches. Our areas of interest revolve around the study of RNA and the regulation of protein subcellular localization.
We are currently particularly interested in:
-the biogenesis and function of small RNAs
-the genomic characterization of the targets of RNT1, prototypical type III yeast endonuclease
-the regulation of protein subcellular localization at the level of splicing
-the combinatorial action of splicing factors
-G-quadruplex identification and function
Our approach combines careful curation of the literature, analysis of high-throughput datasets (and in particular deep-sequencing datasets) and data integration to create predictors and models of molecular classes, biological pathways and systems. Please watch the tools section as our databases and predictors become available.
We collaborate closely with wetlab research groups to generate our datasets and test our analyses and predictions in an iterative manner. Several members of our group are members of members of others such groups including Sherif Abou-Elela's and Jean-Pierre Perreault's groups.
March 23, 2018
Jan. 8, 2018
Sept. 5, 2017
May 15, 2017
Jan. 5, 2017
Aug. 30, 2016
June 15, 2016
Jan. 4, 2016
Dec. 15, 2015
Aug. 31, 2015